Olson, K R Levy, J K Norby, B Crandall, M M Broadhurst, J E Jacks, S Barton, R C Zimmerman, M S Inconsistent identification of pit bull-type dogs by shelter staff. The aim of this report is to increase awareness of the condition, assist diagnosis in encephalopathic dogs and improve detection of carriers amongst breeding stock. This report discusses the advantages and limitations of the three main diagnostic modalities, namely: magnetic resonance imaging, urine gas chromatography-mass spectrometry and genetic testing. Affected dogs have normal haematology, serum biochemistry and routine urine analysis. Although this is the first reported case in South Africa, at least three other affected dogs have been indentified by polmerase chain reaction (PCR in this country.
Amongst canines, the condition has been best described in Staffordshire Bull Terriers. Some affected dogs show only subtle behavioural changes. The most common presenting signs are seizures, tremors, ataxia and/ or dementia.
L-2 hydroxyglutaric aciduria in a South African Staffordshire Bull Terrierĭirectory of Open Access Journals (Sweden)įull Text Available L-2 hydroxyglutaric aciduria is an autosomal recessive error of metabolism that manifests as an encephalopathy.
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